|Molar mass||65.01 g/mol|
|Appearance||white crystalline solid|
|Melting point||550 °C (1,022 °F; 823 K)|
|11.6 g/100 mL (25 °C)|
|Solubility||ethanol: 0.22 g/100 mL (0 °C)
dimethylformamide: 0.05 g/100 mL (25 °C)
slightly soluble in ammonia, benzene
insoluble in diethyl ether
|Crystal structure||body centered rhombohedral|
|86.6 J/mol K|
|119.2 J/mol K|
Std enthalpy of
LD50 (Lethal dose)
|1500 mg/kg (rat, oral)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
One of the more recent methods of synthesis involves modifying a procedure in the production of fatty alcohols. Instead of quenching the reaction with water, ammonia is added. This allows for the ammonia to evolve into cyanate and drop out of solution as a precipitate. The precipitate is 95-97% pure with traces of bicarbonate in it. This solid is then rinsed off with water leaving sodium cyanate that has a high purity.
Sodium cyanate is a useful reagent in producing asymmetrical urea that have a range of biological activity mostly in aryl isocyanate intermediates. Such intermediates as well as sodium cyanate have been used in medicine as a means of counterbalancing carcinogenic effects on the body, possibly helping people with sickle cell anemia, and blocking certain receptors for melanin which has been shown to help with obesity. In most cases the intermediates produced with sodium cyanide are used for medicinal study however, in the cases of sickle cell anemia and anti-carcinogenic research Sodium Cyanate itself was the compound of interest.
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- Waddington, T.C. "Journal of the Chemical Society (Resumed)." 499. Lattice Parameters and Infrared Spectra of Some Inorganic Cyanates - (RSC Publishing). N.p., n.d. Web. 09 Nov. 2014.
- Kamlet, Jonas "Patent US2563044 A - Concurrent manufacture of sodium cyanate and fatty alcohols." Google Books. N.p., n.d. Web. 09 Nov. 2014.
- Expedient Synthesis of Chiral Oxazolidinone Scaffolds via Rhodium-Catalyzed Asymmetric Ring-Opening with Sodium Cyanate Gavin Chit Tsui, Nina M. Ninnemann, Akihito Hosotani, and Mark Lautens Organic Letters 2013 15 (5), 1064-1067
- see 7.)
- Inhibition of Carcinogen-induced Neoplasia by Sodium Cyanate, tert-Butyl Isocyanate, and Benzyl Isothiocyanate Administered Subsequent to Carcinogen Exposure Lee W. Wattenberg Cancer Res August 1981 41:2991-2994
- STUDIES WITH INTRAVENOUS SODIUM CYANATE IN PATIENTS WITH SICKLE CELL ANEMIA Charles M. Peterson, Yang S. Lu, John T. Herbert, Anthony Cerami, and Peter N. Gillette J Pharmacol Exp Ther June 1974 189:577-584; published online June 1, 1974,
- Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas Ekaterina V. Vinogradova, Brett P. Fors, and Stephen L. Buchwald Journal of the American Chemical Society 2012 134 (27), 11132-11135
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