Sodium picosulfate
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| Systematic (IUPAC) name | |
| disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| Identifiers | |
| CAS number | 10040-45-6  |
| ATC code | A06AB08 A06AB58 (combinations) |
| PubChem | CID 68654 |
| ChemSpider | 61910  |
| UNII | LR57574HN8 |
| Chemical data | |
| Formula | C18H13NNa2O8S2 |
| Mol. mass | 481.409 g/mol |
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Sodium picosulfate (INN, also known as sodium picosulphate) is a contact laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Sodipic Picofast, Laxoberal, Laxoberon,[1] Purg-Odan, Picolax, Picoprep,[2] Guttalax, and Pico-Salax[3] among others.
Effects [edit]
Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It works very quickly, so access to a toilet at all times is recommended. It starts off by making bowel movements looser and more frequent, but within an hour or so of taking it the patient should experience diarrhea.
The most common side effects of picosulfate are abdominal cramps and diarrhea.
The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.[4] Patients are often required to drink large amounts of clear fluids to reestablish the electrolyte balance as well as rehydrate.[5]
On July 16, 2012 the FDA approved Prepopik, a formulation containing sodium picosulfate, magnesium oxide, and citric acid, for use as a bowel cleanser in preparation for colonoscopy. [6]
References [edit]
- ^ Website of Merck Pakistan
- ^ Picoprep study at ingentaconnect 'Picoprep-3 Is a Superior Colonoscopy Preparation to Fleet: A Randomized, Controlled Trial Comparing the Two Bowel Preparations' study at St George Hospital, Sydney, NSW, Australia
- ^ PICO SALAX Product Information
- ^ ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull 21 (1). Free full text from the Australian Therapeutic Goods Administration
- ^ http://www.odanlab.com/picodan/purgodan/PurgOdan_patient_en.pdf
- ^ FDA approves new colon-cleansing drug for colonoscopy prep
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