Solvent casting and particulate leaching

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In solvent casting and particulate leaching (SCPL), a polymer is dissolved in an organic solvent. Particles, mainly salts, with specific dimensions are then added to the solution. The mixture is shaped into its final geometry. For example, it can be cast onto a glass plate to produce a membrane or in a three-dimensional mold to produce a scaffold. When the solvent evaporates it creates a structure of composite material consisting of the particles together with the polymer. The composite material is then placed in a bath which dissolves the particles, leaving behind a porous structure.[1]


  1. ^ Liao CJ, Chen CF, Chen JH, Chiang SF, Lin YJ, Chang KY (March 2002). "Fabrication of porous biodegradable polymer scaffolds using a solvent merging/particulate leaching method". Journal of Biomedical Materials Research 59 (4): 676–81. doi:10.1002/jbm.10030. PMID 11774329.