Somatomedins are a group of hormones that promote cell growth and division in response to stimulation by growth hormone (GH), which is also called somatotropin (STH).
They have similar biological effects to somatotropin.somatomedins belong to the insulin family.
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.