Sophia, as she is often referred to in Portugal, was born in Porto to a wealthy aristocratic family. She inherited the surname 'Andresen' from her paternal grandfather, a Danish merchant. She received a strict Catholic upbringing, and was to remain a fervent believer until the end of her life. After spending her childhood in Porto she moved to Lisbon, where she attended the Universidade de Lisboa. As a student, she was activelly involved in Catholic movements. Politically, she defended constitutional monarchy and openly criticized Salazar's dictatorship. In 1946 she married lawyer and politician Francisco Sousa Tavares. They had five children, among whom journalist and best-selling author Miguel Sousa Tavares. After the Carnation Revolution in 1974, she made a brief incursion into politics as an MP for the Socialist Party (centre-left).
Andresen won acclaim as a storyteller with Contos Exemplares (Exemplary Tales),"Histórias da Terra e do Mar" (Stories of Land and Sea), and a number of children's books - A Menina do Mar (The Sea Girl), O Cavaleiro da Dinamarca (The Danish Knight), A Floresta (The Forest), O Rapaz de Bronze (The Bronze Boy), A Fada Oriana (The Fairy Oriana). She also published several poetry books and anthologies, including: Poesia, Dual, Livro Sexto, Coral, Dia do Mar, No Tempo Dividido, Grades, O Nome das Coisas, As Ilhas, Antologia, Geografia, Navegações, O Búzio de Cós. In 1999 she became the first woman to receive the highest Portuguese award for poetry, the Prémio Camões. She was also awarded the Spanish Premio Reina Sofia in 2003.
"Poetry," she explained, "is my understanding of the universe, my way of relating to things, my participation in reality, my encounter with voices and images. This is why the poem speaks not of an ideal life but of a concrete one: the angle of a window, the resonance of streets, cities and rooms, the shadow cast by a wall, a sudden face, the silence, distance and brightness of the stars, the night’s breath, the scent of linden and of oregano." The sea is probably the most central theme in her poetical works. Other recurring themes are Ancient Greece and ideas of freedom and justice.
Besides her work as a writer, she translated Dante and Shakespeare into Portuguese.