She was born Sophie Irene Simon. She was a school teacher in McKeesport, Pennsylvania, at the East End Public School before she married Ansel F. Loeb, in 1896. In 1912, she wrote the book, Epigrams of Eve, with illustrations by Ruby Lind (Ruby Lindsay.)
She was the president of the Board of Child Welfare of New York for seven years, and in 1921 she established the first child welfare building. In 1924, she became president of the Child Welfare Committee of America.