Sorangium cellulosum
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| Myxobacteria | |
|---|---|
| Scientific classification | |
| Kingdom: | Bacteria |
| Phylum: | Proteobacteria |
| Class: | Delta Proteobacteria |
| Order: | Myxococcales |
| Genus: | Sorangium |
| Species: | cellulosum |
Sorangium cellulosum is a soil-dwelling Gram-negative bacterium of the group myxobacteria.[1] It is motile and shows gliding motility. It has an unusually-large genome of 13,033,779 base pairs, making it the largest bacterial genome sequenced to date.[2]
[edit] Clinical use
Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity.[3] This has led to the development of analogs which mimic its activity. One such analog, known as Ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of metastatic breast cancer.[1]
[edit] References
- ^ Julien B, Fehd R (2003). "Development of a mariner-based transposon for use in Sorangium cellulosum.". Appl Environ Microbiol 69 (10): 6299–301. doi:10.1128/AEM.69.10.6299-6301.2003. PMC 201241. PMID 14532095. http://aem.asm.org/cgi/content/full/69/10/6299?view=long&pmid=14532095.
- ^ Schneiker S et al. (2007). "Complete genome sequence of the myxobacterium Sorangium cellulosum". Nature Biotechnology 25 (11): 1281–1289. doi:10.1038/nbt1354. PMID 17965706.
- ^ Lee FY, Borzilleri R, Fairchild CR, et al. (December 2008). "Preclinical discovery of ixabepilone, a highly active antineoplastic agent". Cancer Chemother. Pharmacol. 63 (1): 157–66. doi:10.1007/s00280-008-0724-8. PMID 18347795.
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