Sorivudine

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Sorivudine
Sorivudine.svg
Systematic (IUPAC) name
1-β-D-arabinofuranosyl-5-[(E)-2-bromovinyl]pyrimidine-2,4(1H,3H)-dione
Clinical data
Legal status ?
Routes oral
Pharmacokinetic data
Metabolism Viral thymidine kinase
Excretion kidney
Identifiers
CAS number 77181-69-2 YesY
ATC code J05AB15
PubChem CID 5282192
UNII C7VOZ162LV N
KEGG D01734 YesY
ChEMBL CHEMBL375035 N
Synonyms BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Chemical data
Formula C11H13BrN2O6 
Mol. mass 349.14 g/mol
 N (what is this?)  (verify)

Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).

Pharmacology[edit]

Feature[edit]

  • First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
  • Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.

Mechanism of action[edit]

  • Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.

Microbiology[edit]

Sorivudine is active against most species in the herpesvirus family.