The west terminus of SC 296 is at a junction with SC 14 in west-central Greenville County and proceeds in a generally east-northeast direction. Shortly after the junction, the route merges with SC 146, but soon separates from SC 146 a short distance afterward. South Carolina Highway 296 then crosses into Spartanburg County as it traverses the Enoree River, and then intersects with SC 101 before passing through Reidville. Then, SC 296 intersects with SC 290 and SC 417 before intersecting with Interstate 26 at exit 22 just outside the Spartanburg city limits. Within the city, SC 296 junctions with US 29 and US 221, and finally reaches its eastern terminus with US 176 and SC 9.