SC 37 is an original state highway, established in 1922. Its original routing was from SC 1, in Barnwell, to SC 27, in Williston. In 1923, SC 37 was rerouted to Elko, leaving behind Williston Way (S-6-113). In 1940, SC 37 was extend in both directions: north to SC 39; south through Barnwell, in concurrency with SC 3, to the Barnwell-Allendale county line. By 1942, a separate section of SC 37 was established on primary routing from SC 73/SC 631, southeast of Allendale, to north of SC 28, in Baldock. By 1946, the two sections were combined, reaching its apex of nearly 40 miles (64 km) long. In 1948, SC 37 was truncated to US 78, in Elko; but in the following year, it was re-extended back to SC 39. In 1962 or 1963, SC 37 was truncated at its current southern terminus with SC 28, north of Barnwell; its former alignment south replaced by SC 3.