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The region's history and geography has led to a blend of Northern and Southern culture distinct from the remainder of Indiana. It is often considered to be part of the Upland South. Southern Indiana was the first area of the state to be settled, and Indiana's first state capital was located in Corydon in Harrison County near the Ohio River. The city of Vincennes, located in the region, is the oldest continually inhabited settlement in Indiana and was the first capital of the Indiana Territory.
The Catholic Church has a significant presence in the region. Noteworthy Catholic institutions in Southern Indiana include St. Meinrad Archabbey, one of two Catholic archabbeys/seminaries in the United States and Mount St. Francis, a large retreat center in Floyd County.
Southern Indiana also differs from the rest of the state linguistically. The South Midland dialect of American English is prevalent, as opposed to the Inland North dialect in far Northern Indiana and the North Midland dialect in Central and North-Central Indiana. Southern Indiana is the northernmost extent of the South Midland region, forming what linguists refer to as the "Hoosier Apex" of the South Midland dialect.
Southern Indiana's topography is considerably more varied and complex than Central and Northern Indiana, and includes large tracts of forest (such as the Hoosier National Forest), rolling fields, and sharp hills. Its elevation ranges from around 360 feet (110 m) at the large wide largely flat valleys near the mouth of the Wabash River along the southwest to the chain of hills 800-1,000 ft.(244-305m) high called the Knobstone Escarpment, or simply "The Knobs in the south central and southeast." The region also includes the oldest exposed Devonian fossil beds in the world at the Falls of the Ohio state park in Clarksville.
The region's largest city is Evansville, in the southwest corner of the state. As of the 2000 census, the city had a total population of 121,582, and a metropolitan population of 342,815. The south-central counties of Clark, Floyd, and Harrison are part of the greater Louisville, Kentucky metropolitan area and have a combined population of over 200,000.
Major highways 
Colleges and universities 
Several notable colleges and universities are located in Southern Indiana.
- Hanover College
- Indiana University (Bloomington)
- Indiana University Southeast
- Indiana University-Purdue University Columbus (IUPUC)
- Oakland City University
- Saint Meinrad School of Theology
- University of Evansville
- University of Southern Indiana
- Vincennes University
Professional sports 
There are two professional sports teams in the region, both located in Evansville - the Evansville IceMen (founded in 2008) participate in the "Double-A" Central Hockey League (CHL), and the Evansville Otters (founded in 1995) play in baseball's independent Frontier League.
College sports 
National Collegiate Athletic Association Division I
National Collegiate Athletic Association Division II
- Southern Indiana Screaming Eagles (Vanderburgh County)
National Collegiate Athletic Association Division III
- Hanover Panthers (Jefferson County)
National Christian Collegiate Athletic Association (NCCAA) Division II
- Oakland City Mighty Oaks (Gibson County)
National Association of Intercollegiate Athletics (NAIA)
- IU Southeast Grenadiers (Floyd County)
National Junior College Athletic Association (NJCAA)
- Vincennes Trailblazers (Knox County)
See also 
- Southern Illinois
- Southern Ohio
- Evansville, Indiana
- Louisville Metropolitan Area
- Cincinnati Metropolitan Area
- Evansville Metropolitan Area
- University of Southern Indiana
- Geography of Indiana
- Southwestern Indiana
- Illinois-Indiana-Kentucky Tri-State Area
- Wabash Valley