Space Frontier usually involves a particular species (normally humans) departing their native home planet into outer space to other regions of space for the purpose of exploration, transportation, colonization, adventure or all of those.
Another common depiction in Space Frontier is contact between humans (or whichever species is shown traveling) and another species that live in the uncharted region of space. Mutual co-operation or conflict between the two civilizations is also a common occurrence.
Space Frontier can also have other concepts of contact between space explorers and primitive yet sometimes destructive lifeforms such as viruses, bacteria or creatures of an unknown type.
Space Frontier is similar to Space Western in respect to space travel, intergalactic/multi-planetary adventure, however unlike Space Western, Space Frontier does not primarily include American West as a main theme.