Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that affects all four limbs (both arms and legs). Formerly known as Little's Disease, it was first discovered and medically defined in 1861 by Dr. William John Little in his lecture "Hospital for the Cure of Deformities: Course of Lectures on the Deformities of the Human Frame." .
Compared to quadriplegia, spastic quadriplegia is defined by spasticity of the limbs as opposed to strict paralysis. It is distinguishable from other forms of cerebral palsy in that those afflicted with the disease display stiff, jerky movements, as well as hypertonia of the muscles. There are 8 levels of spastic quadriplegia, with 8 being the least severe and 1 being the most severe. This differs from non-spastic cerebral palsy, which causes decreased muscle tone.
Spastic quadriplegia, while affecting all four limbs more or less equally, can still present parts of the body as more spastic than others, such as one arm being tighter than another arm, and so forth. Spastic triplegia, meanwhile, involves three limbs (such as one arm and two legs, or one leg and two arms, etc.); spastic diplegia affects two limbs (commonly just the legs), spastic hemiplegia affects one or another entire side of the body (left or right); and spastic monoplegia involves a single limb.
Spastic quadriplegia is most commonly caused by brain trauma before birth, but there may also be genetic factors. It is typically detected early in development, and there are currently no known cures for the disease. However, treatment options include medication, surgery, and physical therapy.
Spastic quadriplegia can be detected by the abnormal development of motor skills in children. Symptoms can present themselves as early as three months but are generally seen before the child reaches two years of age. Some warning signs include: a child of more than two months who has stiff legs that scissor and is unable to control his or her head, and a child of more than twelve months who has not developed the ability to crawl or stand.
Spastic quadriplegia also presents a range of symptoms that affect the musculature. Many experience contractures, which are defined as joints that cannot be stretched or moved. Clonus is another symptom that is characterized by alternating, rapid muscle contraction and relaxation. This presents itself as tremors and scissoring of the limbs. Distonia, or lasting muscle contractions and tightness, is also often experienced by those affected by spastic quadriplegia. These involuntary muscle contractions may affect the development of structural muscle around the hip and lead to hip dysplasia and dislocation, making it difficult to sit. The combination of these symptoms often makes it difficult for the patients to walk as well. Although the arms and legs of patients are often stiff, the neck is usually limp due to the lack of voluntary muscle control.
The disease is also characterized by its effects on the digestive system leading to difficulty speaking, chewing, breathing, and swallowing. Patients may experience vomiting, constipation, and incontinence. It has also been found that those with spastic quadriplegia often times experience stunted growth.
The disease can also exert its effects more directly on the central nervous system. Many patients exhibit moderate to severe learning disabilities and decreased intellect. They may also experience hearing and vision problems along with seizures.
Spastic quadriplegia is generally caused by brain damage or disruptions in normal brain development preceding birth. According to the National Institutes of Health, there are four types of brain damage that can cause spastic quadriplegia. These include, damage to the white matter (periventricular leukomalacia), abnormal brain development (cerebral dysgenesis), bleeding in the brain (intracranial hemorrhage), and brain damage due to lack of oxygen (hypoxic-ischemic encephalopathy or intrapartum asphyxia).
The white matter of the brain is especially vulnerable between the 26th and 34th weeks of maturation, and damage to the white matter can interfere with the brain’s ability to transmit signals to the rest of the body. Spastic quadriplegia can be caused by a condition known as periventricular leukomalacia which results in the formation of lesions and holes in the white matter of the brain.
Prior to the 26th week of maturation, the fetal brain is particularly susceptible to various toxins whose effects can ultimately hinder normal development. Exposure of the brain to infectious agents is especially dangerous because they can trigger immune responses that activate cytokines and lead to inflammation of the brain. Some infections that have been linked to the development of spastic quadriplegia include meningitis, herpes, rubella, and encephalitis. A difference in blood types between the mother and the fetus can also initiate a problematic immune response and cause brain damage. Severe jaundice, can also lead to brain damage and spastic quadriplegia due to a buildup of bilirubin in the blood.
Bleeding in the brain caused by fetal strokes, blood clots, weak and malformed blood vessels, or high maternal blood pressure may also lead to brain damage causing spastic quadriplegia. Maternal infection, most specifically pelvic inflammatory disease, has been shown to increase the risk of fetal stroke.
Hypoxia, lack of oxygen to the brain, can also cause damage in the cerebral motor cortex and other brain regions. This lack of oxygen can be the result of placenta malfunction, womb rupture, umbilical cord damage, low maternal blood pressure or asphyxia during labor and delivery.
Recent studies suggest that there may be a genetic link to spastic quadriplegia.
Children who experienced many complications during birth, such as, prematurity, insufficient oxygen, low birthweight, aspiration, head injury, or bleeding in the brain have a greater risk of developing spastic quadriplegia. Children whose mothers were ill during the pregnancy or did not receive adequate nutrition are also more likely to develop the disease.
Testing and diagnosis 
Spastic quadriplegia can be diagnosed as early as age one after a noticed delay in development, particularly a delay in rolling, crawling, sitting, or walking.  However, depending on the severity, signs may not show up until the age of three. Muscle tone is sometimes used to make the diagnosis for spastic quadriplegia as affected children often appear to be either too stiff or too floppy.
Another important diagnostic factor is the persistence of primitive reflexes past the age at which they should have disappeared (6–12 months of age). These reflexes include the rooting reflex, the sucking reflex, and the Moro reflex, among others.
Because cerebral palsy refers to a group of disorders, it is important to have a clear and systematic naming system. These disorders must be non-progressive, non-transient, and not due to injury to the spinal cord Disorders within the group are classified based on two characteristics- the main physiological symptom, and the limbs that are affected. For a disorder to be diagnosed as spastic quadriplegia, an individual must show spastic symptoms (as opposed to athetotic, hypertonic, ataxic, or atonic symptoms) and it must be present in all four limbs (as opposed to hemiplegic, diplegic, or triplegic cases).
While a diagnosis may be able to be made shortly after birth based on family history and observation of the infant, it is often postponed until after the child is between 18–24 months old in order to monitor the possible regression or progression of symptoms.
Because spastic quadriplegia can be caused by physical trauma or by onset of a disease resulting in damage to the brain or spinal cord, it can occur at any age. However, those who experience complications during birth, premature birth, or other health problems as an infant, are especially prone to develop spastic quadriplegia. As a result of the disease, patients may experience mental retardation or have communication problems. Bulbar involvement can cause oral motor dysfunctions and feeding problems due to difficulty in chewing and swallowing leading to aspiration and gastric reflux. As in cerebral palsy, infants may have poor color, weak breathing and develop seizures.
Due to the inability to voluntarily move all four limbs, people are usually confined to beds or wheelchairs. Confinement to beds and wheelchairs can then cause pressure sores, spastic jerking, and respiratory problems. Spastic quadriplegia can also affect intelligence and lead to the development of mental retardation. However, it can be difficult to determine the severity of the learning disability due to speech and communication problems. Other complications include scoliosis, diminished joint flexibility and difficulty in swallowing. Bladder and bowel control, digestion, and breathing are also affected.
There is no cure for spastic quadriplegia, and treatment revolves around preventing complications and allowing the patient to live as independently as possible. Treatment is generally symptomatically focused, rather than etiological. Several aims of treatment are alleviating pain and controlling spasticity, which, if untreated, can lead to complications. Common medications for controlling spasticity are benzodiazepines, muscle relaxants such as baclofen, and botulinum toxin. Diuretics and steroids can be used to prevent and release fluid buildup in the spine.
Surgery can be used to control pain and spasticity by severing nerves from the spinal cord. Surgery is also used to release contractures, or to place a feeding tube if needed. Like all other forms of cerebral palsy, physical therapy is often used to strengthen the limbs in order to prevent contractures and to improve motor skills. Deep brain stimulation has been reported to benefit young children with dystonic symptoms. In severe cases, a selective dorsal rhizotomy may be performed in order to reduce spasticity in the legs.
Often, different support mechanisms can be of benefit to those with spastic quadriplegia. Muscle and bone braces, wheelchairs, and walking aids, scooters, and tricycles can be used to aid in mobility. An abdominal binder can provide support to the torso that is commonly slack due to weak abdominal muscles.
Occupational therapists may be a key component in the treatment of those with spastic quadriplegia, as they help children learn skills such as feeding and dressing. Speech therapy or voice synthesizers may be used in cases where speech problems are an issue. It is also important that care for someone with spastic quadriplegia be continued at home, including good nutrition and practicing prescribed exercises.
Scientific classification 
The scientific classifications for these types include:
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