Spectral skewing

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Spectral skewing is the changes in relative intensities of mass spectral peaks due to the changes in concentration of the analyte in the ion source as the mass spectrum is scanned; this situation occurs routinely as chromatographic components elute into a continuous ion source.

Spectral skewing is not observed in ion trap (quadrupole (this has been seen also in QMS) or magnetic) or time-of-flight (TOF) mass analyzers because potentially all ions formed in operational cycle (a snapshot in time) of the instrument are available for detection.


  • Watson, J. THrock, Sparkman,O David.Introduction to Mass Spectrometry.John Wiley & Sons, Inc. 4th Edition,2007. Page:113