|Molar mass||145.25 g·mol−1|
|Density||925 mg mL−1|
|Melting point||22 °C (72 °F; 295 K)|
|145 g L−1 (at 20 °C)|
|UV-vis (λmax)||260 nm|
Refractive index (nD)
|GHS signal word||DANGER|
|P280, P305+351+338, P310|
|Flash point||112 °C (234 °F; 385 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Polyamines, such as spermidine, are polycationic aliphatic amines and are multifunctional. They serve vital roles in cell survival.
Spermidine synchronizes an array of biological processes (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral cortex synaptosomes.
Spermidine is a longevity agent due to its impact on chromatin-mediated regulation of gene expression, however the mechanism is poorly understood. Spermidine synthase (SPDS) catalyzes the formation of spermidine. Spermidine helps further polyamines, this can include polyamines and thermospermine. These contribute to a resistance of dry climate and salinity.
It is known to regulate plant growth, assisting the in vitro process of transcribing RNA, and inhibition of NOS. Also, spermidine is a precursor to polyamines, such as spermine and thermospermine, most of which contribute to tolerance against drought and salinity in plants.
Spermidine has been tested and discovered to encourage hair shaft elongation and lengthen hair growth. Spermidine has also been found to “upregulate expression of the epithelial stem cell-associated keratins K15 and K19, and dose-dependently modulated K15 promoter activity in situ and the colony forming efficiency, proliferation and K15 expression of isolated human K15-GFP+ cells in vitro.”
Spermidine's known actions include:
- Inhibits neuronal nitric oxide synthase (nNOS)
- Binds and precipitates DNA
- Polyamine plant growth regulator
Polyamines are ubiquitous in the animal, fungi, and plant kingdoms. Therefore, they appear in a wide array of foodstuff. There is a popular myth that grapefruits contain high amounts of spermidine, which probably relies on the confusion between spermidine and putrescine. While citrus fruits show high amounts of putrescine, they contain very little spermidine. Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains. In grains, the endosperm contains most of the spermidine. The most concentrated known dietary source is wheat germ, containing as much as 243 mg/kg.
- Spermidine can be used in electroporation while transferring the DNA into the cell under the electrical impulse. May be used for purification of DNA-binding proteins.
- Spermidine is also used, along with calcium chloride, for precipitating DNA onto microprojectiles for bombardment with a gene gun.
- Spermidine has also been found to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. Recently Tirupathi Pichiah et al., suggested that spermidine may be helpful for treating type 2 diabetes.
- American Heritage Dictionary Retrieved 2014-11-18.
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- Tobias Eisenberg, Heide Knauer, Alexandra Schauer, Sabrina Büttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci, Heike Fussi, Luiza Deszcz, Regina Hart, Elisabeth Schraml, Alfredo Criollo, Evgenia Megalou, Daniela Weiskopf, Peter Laun, Gino Heeren, Michael Breitenbach, Beatrix Grubeck-Loebenstein, Eva Herker, Birthe Fahrenkrog, Kai-Uwe Fröhlich, Frank Sinner, Nektarios Tavernarakis, Nadege Minois, Guido Kroemer, Frank Madeo (4 October 2009). "Induction of autophagy by spermidine promotes longevity,". Nature Cell Biology 11 (11): 1305–14. doi:10.1038/ncb1975. PMID 19801973.
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