Sphincter of ampulla

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sphincter of ampulla
Interior of the descending portion of the duodenum, showing bile papilla.
Latin m. sphincter ampullae
MeSH Oddi's+Sphincter
TA A05.8.02.018
FMA FMA:15077
Anatomical terminology

The sphincter of ampulla or sphincter of Oddi is a muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi.[1] The sphincter of Oddi is relaxed by the hormone cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[2]

Clinical significance[edit]

Opiates can cause spasms of the sphincter of Oddi, leading to increased serum amylase levels.


  1. ^ synd/2709 at Who Named It?
  2. ^ J Clin Invest. 1988 June; 81(6): 1920–1924.
  • Gray's Anatomy, 39th ed. p. 1228.

Further reading[edit]