Sphingosine kinase 1

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Sphingosine kinase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SPHK1 ; SPHK
External IDs OMIM603730 MGI1316649 HomoloGene39748 ChEMBL: 4394 GeneCards: SPHK1 Gene
EC number 2.7.1.91
RNA expression pattern
PBB GE SPHK1 219257 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8877 20698
Ensembl ENSG00000176170 ENSMUSG00000061878
UniProt Q9NYA1 Q8CI15
RefSeq (mRNA) NM_001142601 NM_001172472
RefSeq (protein) NP_001136073 NP_001165943
Location (UCSC) Chr 17:
74.37 – 74.38 Mb
Chr 11:
116.53 – 116.54 Mb
PubMed search [1] [2]

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.[1][2]

Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P) SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of Phospholipase D (PLD)

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.[2]

Interactions[edit]

SPHK1 has been shown to interact with TRAF2.[3]

References[edit]

  1. ^ Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S (Oct 1998). "Molecular cloning and functional characterization of murine sphingosine kinase". J Biol Chem 273 (37): 23722–8. doi:10.1074/jbc.273.37.23722. PMID 9726979. 
  2. ^ a b "Entrez Gene: SPHK1 sphingosine kinase 1". 
  3. ^ Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA (March 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". J. Biol. Chem. 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. PMID 11777919. 

Further reading[edit]

External links[edit]

  • Paugh SW, Kapitonov D, Spiegel S (2007-11-08). "Sphingosine kinase 1". UCSD-Nature Molecule Pages. Signaling Gateway: University of California San Diego (UCSD) and Nature Publishing Group. doi:10.1038/mp.a002219.01. Retrieved 2008-09-15.