Music from and Inspired by Spider-Man 2 reached the top 10 of the U.S. album charts and the top 40 of the Australian album charts. "Vindicated" by Dashboard Confessional reached the top of a world composite soundtrack chart in June 2004 and the top 20 of a composite world and U.S. modern rock chart. "We Are" by Ana Johnsson was a major success in Europe, charting in almost every European country. "Ordinary" by Train was on the U.S. adult top 40 singles charts. "I Am" by Killing Heidi was added to the Australian version of the soundtrack and released as a single in the country. It debuted and peaked at #16 on the ARIA Charts on July 19, 2004.
The song "Where I Belong", by Sia was earmarked to appear on the soundtrack, but owing to a record label conflict, its inclusion was withdrawn. The single's cover art featured Sia dressed in a Spider-Man costume.
On the Polish version of the soundtrack, the single "Chron to co masz" by PtakY appears as track 17.
Although the soundtrack contains a portion of Danny Elfman'sscore, a more complete album of the film music was released as Spider-Man 2: Original Motion Picture Score. Tracks 10 and 11 are listed as "Bonus Tracks" as they were not used in the film (John Debney and Christopher Young reworked several cues of the score, in addition to music from the first film being tracked in).