The story is set shortly after the events of Marvel’s Secret Invasion story line. Therein, the Skrulls infiltrated the Earth, replacing A-list super heroes with their own shape-shifting operatives. Jessica Drew, aka Spider-Woman, was replaced by the Skrull queen Veranke. The series starts with Jessica feeling very poorly about her life due to Veranke's actions. She is approached to join S.W.O.R.D. by agent Abigail Brand, which she accepts. Her first mission takes her to Madripoor where she takes on a Skrull posing as Spider-Man. After run-ins with HYDRA, another Skrull and the new Thunderbolts, Jessica takes down a wayward Skrull with the help of her teammates in the New Avengers. After the mission is over, Brand offers her new opportunities within S.W.O.R.D.