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Protein phosphatase 1, regulatory subunit 9B
Protein PPP1R9B PDB 2g5m.png
PDB rendering based on 2g5m.
Symbols PPP1R9B ; PPP1R6; PPP1R9; SPINO; Spn
External IDs OMIM603325 MGI2387581 HomoloGene32787 GeneCards: PPP1R9B Gene
RNA expression pattern
PBB GE PPP1R9B gnf1h00838 at tn.png
PBB GE PPP1R9B gnf1h00839 at tn.png
More reference expression data
Species Human Mouse
Entrez 84687 217124
Ensembl ENSG00000108819 ENSMUSG00000038976
UniProt Q96SB3 Q6R891
RefSeq (mRNA) NM_032595 NM_172261
RefSeq (protein) NP_115984 NP_758465
Location (UCSC) Chr 17:
48.21 – 48.23 Mb
Chr 11:
94.99 – 95.01 Mb
PubMed search [1] [2]

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.[1][2]

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM][2]


PPP1R9B has been shown to interact with PPP1CB,[3] PPP1CA,[3] Dopamine receptor D2,[4] P16,[5] PPP1CC,[3][4] T-cell lymphoma invasion and metastasis-inducing protein 1[6] and PPP1R2.[7]


  1. ^ Allen PB, Ouimet CC, Greengard P (Oct 1997). "Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines". Proc Natl Acad Sci U S A 94 (18): 9956–61. doi:10.1073/pnas.94.18.9956. PMC 23308. PMID 9275233. 
  2. ^ a b "Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B". 
  3. ^ a b c Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry (UNITED STATES) 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355. 
  4. ^ a b Smith, F D; Oxford G S; Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. (UNITED STATES) 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935. 
  5. ^ Vivo, M; Calogero R A; Sansone F; Calabrò V; Parisi T; Borrelli L; Saviozzi S; La Mantia G (Apr 2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J. Biol. Chem. (United States) 276 (17): 14161–9. doi:10.1074/jbc.M006845200. ISSN 0021-9258. PMID 11278317. 
  6. ^ Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. (United States) 278 (21): 18833–41. doi:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897. 
  7. ^ Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. (United States) 277 (48): 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929. 

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