Splicing regulatory element

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Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.[1]

SREs are:

present in exons: exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs)
present in introns: intronic splicing enhancers (ISEs), intronic splicing silencers (ISSs).


  1. ^ Wang, Zefeng; Christopher B. Burge (May 2008). "Splicing regulation: From a parts list of regulatory elements to an integrated splicing code". RNA 14 (5): 802–813. doi:10.1261/rna.876308. ISSN 1355-8382. PMC 2327353. PMID 18369186. Retrieved 2013-08-15.