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A spore is a biological reproductive mechanism.
Spore may also refer to:
- Spore (2008 video game), a video game by Maxis
- Spore (1991 video game), a video game for MS-DOS
- Spore (1987 video game), a game for the Commodore 64 and ZX Spectrum
- Security Protocols Open Repository
- Spore, West Pomeranian Voivodeship, a village in Poland
- Galaxy of Fear: Spore, a book by John Whitman
- Fungal Asexual Spore
- Diaspore (botany), a plant disseminule
- Endospores, a bacterial, non-reproductive survival mechanism
- Spore-like cells, a specific class of stem cells
- Spore print, a diagnostic character for identifying mushrooms
- Resting spore, created by fungi
- Gaia spore, a subset of the Gaia hypothesis
- Milky spore, a bacterium of the white grubs of Japanese beetles
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