Spore photoproduct lyase

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Spore photoproduct lyase
Identifiers
EC number 4.1.99.14
CAS number 37290-70-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Spore photoproduct lyase (EC 4.1.99.14, SAM, SP lyase, SPL, SplB, SplG) is a radical SAM enzyme that repairs a particular kind of lesion that arises upon UV-radiation of bacterial DNA. This repair mechanism is one of the reasons for the resilience of certain bacterial spores. Through a series of radical reactions the photodimer, 3 5-thyminyl-5,6-dihydrothymine, is disconnected to give back two functional thymine rings.[1][2]

Spore photoproduct lyase (reaction diagram).png

References[edit]

  1. ^ Susan C. Wang and Perry A. Frey (2007). "S-adenosylmethionine as an oxidant: the radical SAM superfamily". Trends in Biochemical Sciences 32 (3): 101. doi:10.1016/j.tibs.2007.01.002. PMID 17291766. Note that the SPL drawings are incorrect in this paper and the erratum
  2. ^ Jeffrey M. Buis, Jennifer Cheek, Efthalia Kalliri, and Joan B. Broderick (2006). "Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily". Journal of Biological Chemistry 281 (36): 25994–26003. doi:10.1074/jbc.M603931200. PMID 16829680. 

External links[edit]