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Sprifermin Other names AS-902330; rhFGF18; L-Methionyl(human fibroblast growth factor 18 (FGF-18, zFGF5)-(1-169)-peptide)[1] : 45 CAS Number UNII Formula C 876 H 1396 N 258 O 256 S 6 Molar mass 19832.6262 g/mol g·mol−1 3D model (JSmol )
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Sprifermin (INN ) (developmental code name AS-902330 ), also known as recombinant human fibroblast growth factor 18 (rhFGF18 ), is a recombinant form of human fibroblast growth factor 18 (FGF18)[1] : 45 which is under development by Merck and Nordic Bioscience for the treatment of osteoarthritis .[2] As a recombinant form of FGF18, sprifermin is a potent agonist of the FGFR2 and FGFR3 .[3] [4]
As of 2017, the drug is in phase II clinical trials for the treatment of osteorthritis.[2] [5]
References
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Angiopoietin CNTF EGF (ErbB)
FGF
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Agonists: Ersofermin
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Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)