Squamous metaplasia

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Micrograph showing squamous metaplasia (centre of image) in an atypical polypoid adenomyoma. H&E stain.

Squamous metaplasia refers to benign non-cancerous change (metaplasia) of (non-squamous) surfacing lining cells (epithelium) to a squamous morphology.

Location[edit]

Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia.[1]

Uterine cervix[edit]

In regards to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium .[2]

Significance[edit]

Squamous metaplasia may be seen in the context of benign lesions (e.g. atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma).

See also[edit]

References[edit]

  1. ^ Goralczyk, R (2009). "ß-Carotene and Lung Cancer in Smokers: Review of Hypotheses and Status of Research". Nutrition and Cancer 61 (6): 767–774. doi:10.1080/01635580903285155. PMID 20155614. 
  2. ^ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007) Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 716-720 ISBN 978-1-4160-2973-1