The area was settled by mostly German immigrants from Bavaria in the 1900s. The housing stock is composed of bungelow and shotgun houses. St Stephen's Cemetery, established 1851, is located in the northern part of the neighborhood. The three Jewish cemeteries, Temple Cemetery, Adath Jeshuran Cemetery, and Keneseth Israel Cemetery are located next to each other in the southern part, more commonly referred to as the Bradley neighborhood.
St. Joseph's boundaries are I-65 to the west, Norfolk Southern Railroad to the north, Eastern Parkway to the south and Shelby Street to the east.
As of 2000, the population of Saint Joseph was 1,590 , of which 83.6% are white, 11.4% are black, 4.8% are listed as other, & Hispanics are 0.3%. College graduates are 15.8%, people without a high school degree are 25%, people with 1+ years of college w/o a degree are 10.9%. Females are 50.8% of the population, males are 49.2%.