The church can trace its origins back to the founding of the city of Dubuque, when Methodist Ministers arrived in the city and began work with the miners in the city.
The present church was built in 1896, and the congregation began worshiping in the building in 1897. The church is noted for the collection of TiffanyStained glass windows. It has been called "one of the five finest Religious Tiffany collections in the world." The Angel in the window of the Angel among the Lilies is rumored to bear the likeness of the young deceased daughter of the people who had sponsored that particular window.
The pipe organ in the church is also of historic interest. When the Farand and Votey organ was purchased, two train cars were required to bring the parts to Dubuque. Because the train could not get across the river, barges than were used to float the parts over so that they could be installed in the church. The organ has about 1,000 pipes. At the time of installation, it was one of the largest organs in the area, however over the years it has been eclipsed by others. The pipe organ contains 36 ranks or pipes, about 2,200 total and was restored in 1992 by the Fowler Organ Company, Lansing, Mi.