Between the 1520s and 1540s the church was a center of the Swabian reformerMatthäus Alber, who spread the teachings of Martin Luther to Reutlingen and surrounding areas. The church was heavily damaged during a fire in 1726. From 1893-1901 it was rebuilt in Neo-Gothic style. On the 71-meter high west tower shines a gilded angel from 1343.
The church has been a National Cultural Landmark since 1988.