St. Vincent's Academy was opened in June 1845 by the Sisters of Mercy as the Convent and Academy of Saint Vincent dePaul. Under the leadership of Mother Vincent Mahoney, the Sisters of Mercy from Charleston, South Carolina began the boarding school, an orphanage, a day school and a free school. The St. Vincent's Convent became an independent Motherhouse within two years. More than 20 schools, hospitals, and orphanages were founded throughout Georgia from the Motherhouse. A few early foundations that continue in service include: St. Mary's Home, Savannah (1875), and St. Joseph's Hospital (1880).
Each year, St. Vincent's Academy honors an alumna with the Catherine McAuley Award. The award is given to a person who exemplifies the attributes of Catherine McCauley and, therefore, exemplifies the ideals of St. Vincent's Academy while a student and throughout her life.
Each October, St. Vincent's Academy presents St. Vincent's Annual Tour of Homes and Tea, a self-guided tour of the original 1845 Convent building and eight private homes in Savannah’s Historic District. Proceeds from the Tour and Tea benefit the preservation and restoration of the Convent.