State Highway 50 is a state highway in northeast Texas from State Highway 24 near Commerce northward to Ladonia. It previously extended northward from Ladonia to Honey Grove, concurrent with State Highway 34, and southward to Interstate 30, concurrent with State Highway 24. The duplications of these highway were removed in 2003 and 2009, respectively.
SH 50 was originally proposed by 1926 renumbering a portion of SH 2 between Henrietta and Bowie, when the route of SH 2 was readjusted farther east. This designation was short-lived, as it was replaced by 1939 by U.S. Highway 380.