U.S. Route 52 in Virginia
|Maintained by VADOT|
|Length:||85 mi (137 km)|
|Existed:||mid-1930s – present|
|South end:||US 52 near Mount Airy, NC|
| US 58 in Hillsville
US 21 in Wytheville
|North end:||I-77 / US 52 near Bluefield, WV|
Route description 
U.S. 52 enters Virginia from West Virginia, and in Virginia closely follows Interstate 77. It enters southwestern Virginia near Bluefield and passes through Wytheville and Hillsville before leaving the state south of Cana.
The piece of US 52 south of Fort Chiswell was part of the state highway system defined in 1918. It was initially designated State Route 12-Z, at least south of Hillsville, but by 1924 it was State Route 15. In 1926, the U.S. Route 121 designation was applied to the whole length of SR 15, from North Carolina to Fort Chiswell, but it did not turn west on U.S. Route 11 at Fort Chiswell to connect to U.S. Route 21.
An extension of SR 15 from Fort Chiswell north to Max Meadows was added to the state highway system in 1931. In the 1933 renumbering, SR 15 was dropped from the US 121 concurrency, while the short extension to Max Meadows became State Route 121.
US 121 was absorbed by an extension of US 52 by 1935. US 52 was extended through West Virginia and along U.S. Route 21 to Wytheville and U.S. Route 11 to Fort Chiswell, where it replaced US 121 into North Carolina.
Major intersections 
|Carroll||Cana||0.00||US 52 south – Mount Airy||Southern terminus of US 52 in Virginia; North Carolina state line|
|Fancy Gap||Blue Ridge Parkway||Interchange|
|9.42||SR 148 west (Chances Creek Road) to I-77|
|Hillsville||16.43||US 58 / US 221 (Stuart Drive) – Galax, Stuart, Floyd|
|Wythe||Fort Chiswell||34.67||I-81 north / I-77 south / US 11 north / SR 121 north (Max Meadows Road) – Roanoke, Hillsville||I-81 Exit 80; south end of concurrency with I-81 / I-77 / US 11|
|Wytheville||40.28||US 11 west (Main Street) – Wytheville||I-81 Exit 73; north end of concurrency with US 11|
|41.57||I-77 north – Bluefield, Charleston||I-81 Exit 72; north end of concurrency with I-77|
|43.56||I-81 south / US 21 south (4th Street) – Bristol||I-81 Exit 70; north end of concurrency with I-81|
|Bland||59.62||SR 42 south (Blue Grass Trail) – Saltville||South end of concurrency with SR 42|
|Bland||63.59||I-77 – Wytheville, Bluefield||I-77 Exit 52|
|64.50||SR 42 (Blue Grass Trail) – Pearisburg||North end of concurrency with SR 42|
|Rocky Gap||77.27||SR 61 west (Clear Fork Creek Road) – Tazewell||South end of concurrency with SR 61|
|77.33||I-77 – Wytheville, Bluefield||I-77 Exit 64|
|77.73||SR 61 east (Wolf Creek Highway) – Pearisburg||North end of concurrency with SR 61|
|79.92||I-77 south / SR 598 north – Wytheville, Bluefield||I-77 Exit 66; south end of concurrency with I-77|
|80.62||I-77 north / US 52 north – Charleston||Northern terminus of US 52 in Virginia; East River Mountain Tunnel at West Virginia state line|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
- (PDF) Minutes of the First Meeting of the State Highway Commission Created Under the Acts of 1922, Held July 5th, 1922, Richmond, Va. (Report). Commonwealth of Virginia. http://www.virginiadot.org/meetings/minutes_pdf/CTB-07-1922-01.pdf. , Proposed "State Highway System" for Virginia, as Recommended by the State Roads Committee, January 1918
- (PDF) Minutes of the Fifth Meeting of the State Highway Commission Held November 8th, 9th, 10th and 11th, Richmond, Virginia (Report). Commonwealth of Virginia. http://www.virginiadot.org/meetings/minutes_pdf/CTB-11-1922-01.pdf. , page 11
- (PDF) Minutes of the Meeting of the State Highway Commission, Richmond, Va. April 10th, and 11th, 1924 (Report). Commonwealth of Virginia. http://www.virginiadot.org/meetings/minutes_pdf/CTB-04-1924-01.pdf. , pages 12-13
- United States System of Highways, November 11, 1926
- United States Numbered Highways, American Highways, April 1927
- (PDF) Minutes of the Meeting of the State Highway Commission of Virginia, Held at Virginia Beach, July 24th and 25th, 1931 (Report). Commonwealth of Virginia. http://www.virginiadot.org/meetings/minutes_pdf/CTB-07-1931-01.pdf. , page 70
- Richard F. Weingroff, U.S. 52 Charleston, South Carolina, to Portal, North Dakota
- "Daily Traffic Volume Estimates Jurisdiction Report: Carroll County" (PDF). Virginia Department of Transportation. 2009. Retrieved 2011-06-15.
- "Daily Traffic Volume Estimates Jurisdiction Report: Wythe County" (PDF). Virginia Department of Transportation. 2009. Retrieved 2011-06-15.
- "Daily Traffic Volume Estimates Jurisdiction Report: Bland County" (PDF). Virginia Department of Transportation. 2009. Retrieved 2011-06-15.
|U.S. Route 52|
|< SR 14||Two‑digit State Routes
|SR 16 >|