At Clarksville, SR 76 and US 79 merge with U.S. Route 41A and continue towards downtown. SR 76 branches away as Riverside Drive along the Cumberland River and forms a bypass to the south of town. It junctions with SR 12 before intersecting 41A again. For four miles (6 km) past this junction, SR 76 widens to a four lane divided highway. It junctions with Interstate 24 (exit 11) and funnels down to a two lane road all the way to Adams.
At Adams, the route is broken and is resumed approximately 1 mile east of Springfield intersecting with SR 49. SR 76 continues east to White House, Tennessee. After crossing beneath Interstate 65 in continues east until it intersects with U.S. Route 31W. It then runs concurrent with U.S. Route 31W north approximately two-tenths of a mile and branches again east. It continues east intersecting with SR 25 and finally ends at its intersection with SR 109 in Portland, TN.