Stem cell educator
The stem cell educator is a device that is claimed to change or "re-educate" the behavior of human immune cells by placing the subjects cells in close proximity to stem cells, so as to alleviate or cure certain autoimmune diseases.
Cord blood-derived multipotent stem cells (CB-SCs) are isolated from human cord blood and act as educators for the patient's immune cells in the chamber. The hydrophobic material from (USP Class VI) plastic Petri dishes tightly binds CB-SCs without interfering with their immune modulating capability.
A single treatment is reported to cause safe and lasting improvement in the patient's own control of blood sugar and hence the practical treatment of type 1 diabetes, by reducing autoimmune attack on the islets of Langerhans cells that produce insulin.
- Yong Zhao, Honglan Wang, Theodore Mazzone (2006 Aug 1). "Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics". Exp Cell Res 312 (13): 2454–2464. doi:10.1016/j.yexcr.2006.04.008. PMID 16716296.
- Yong Zhao, Theodore Mazzone (2010 December). "Human cord blood stem cells and the journey to a cure for type 1 diabetes.". Autoimmun Rev 10 (2): 103–107. doi:10.1016/j.autrev.2010.08.011. PMID 20728583.
- "Stem cell educator therapy in type 2 diabetes". NCT01415726. U.S. National Institutes of Health. February 16, 2012. Retrieved December 11, 2012.
- Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary B Fisk, Randal Skidge, Mark Holterman, Bellur Prabhakar and Theodore Mazzone (2012). "Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells". BMC Medicine 10 (3). doi:10.1186/1741-7015-10-3. PMC 3322343. PMID 22233865.