Stephania tetrandra

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Stephania tetandra
Scientific classification
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Ranunculales
Family: Menispermaceae
Genus: Stephania
Species: S. tetrandra
Binomial name
Stephania tetrandra
S. Moore

Stephania tetrandra is a herbaceous perennial vine of the Menispermaceae family. It grows from a short, woody caudex, climbing to a height of around four meters. The leaves are arranged spirally on the stem, and are peltate, i.e. with the leaf petiole attached near the centre of the leaf. Its root is used in traditional Chinese medicine (TCM).

Etymology in Chinese medicine[edit]

Stephania tetrandra is among the 50 fundamental herbs used in TCM. The standard pinyin according to the Chinese [Herbal] Pharmacopia of the People's Republic of China (Chinese: 中华人民共和国药典; pinyin: Zhonghua Renmin Gongheguo Yao Dian) is: fen fang ji (Chinese: 粉防己; pinyin: fěn fáng jǐ), but it is more commonly known as Han Fang ji (Chinese: 漢防己; pinyin: hàn fáng jǐ). Other plants named fang ji (Chinese: 防己, roughly "snakebite remedy") are sometimes substituted for it. Notable among these is guang fang ji (Chinese: 廣防己; pinyin: guǎng fáng jǐ), Aristolochia fanchi, whose main toxic component is aristolochic acid, a potent carcinogen and nephrotoxin.

Traditional medicine[edit]

Fen fang ji is used in traditional Chinese medicine to dispel wind and dampness to relieve pain and to promote diuresis.[citation needed] It is classified as acrid, bitter and cold. The part used is the root.

Warnings, contraindications[edit]

Guang fang ji preparations can contain toxic amounts of aristolochic acid when Aristolochia fanghi is substituted for Stephania tetrandra. Ingestion can lead to renal failure and even death; Aristolochia is used in TCM only with great caution. In May, 2000, the FDA began detaining any plants or medicines suspected of containing aristolochic acid, unless laboratory testing indicated they were negative for aristolochic acid.[1] The traditional route of ingestion of guang fang ji is via water decoction. Since aristolochic acid has low water solubility, water decoction is believed to be a safer route than taking guang fang ji as an uncooked powder.[2]


Stephania contains tetrandrine, a potent smooth muscle relaxant.[3][4][5] Stephania alkaloids have curare-like action, and can selectively inhibit T-cell-dependent immune reactions. The root contains many isoquinoline alkaloids: tetrandrine (0.6-0.9%), fangchinoline (0.5%), cyclanoline (0.1%) and dimethyltetrandrine iodide (muscle relaxant). The root also contains flavanoids. The main active alkaloids are: tetrandrine (12 to 23 grams/kg) and fangchinoline (0.3–3 mg/kg). Also present are: dimethyltetradine iodide, cyclanoline, menisine, menisidine, oxofangchirine, stephenanthrine, stepholidine and bisbenzylisoquinoline.[6][7]

Other herbs sometimes used as Fang Ji[edit]

Herbs sometimes used as Fang Ji include Cocculus trilobus, C. thunbergii Orbiculatus, Aristolochia fangchi, and Simomenium actum (Japanese Han Fang Ji or Quinfengteng).


  1. ^ "A Success Story on Aristolochic Acid". 
  2. ^ Chen JK and Chen TT (2004). Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press. ISBN 0-9740635-0-9. 
  3. ^ Xu, Wei; Debeb, Bisrat G.; Lacerda, Lara; Li, Jessica; Woodward, Wendy A. (2011). "Tetrandrine, a Compound Common in Chinese Traditional Medicine, Preferentially Kills Breast Cancer Tumor Initiating Cells (TICs) in Vitro". Cancers 3 (2): 2274. doi:10.3390/cancers3022274. 
  4. ^ Ng, LT; Chiang, LC; Lin, YT; Lin, CC (2006). "Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines". The American journal of Chinese medicine 34 (1): 125–35. doi:10.1142/s0192415x06003692. PMID 16437745. 
  5. ^ Chen, YJ (2002). "Potential role of tetrandrine in cancer therapy". Acta pharmacologica Sinica 23 (12): 1102–6. PMID 12466047. 
  6. ^ Choi, HS; Kim, HS; Min, KR; Kim, Y; Lim, HK; Chang, YK; Chung, MW (2000). "Anti-inflammatory effects of fangchinoline and tetrandrine". Journal of Ethnopharmacology 69 (2): 173–9. doi:10.1016/S0378-8741(99)00141-5. PMID 10687873. 
  7. ^ Ma, W; Nomura, M; Takahashi-Nishioka, T; Kobayashi, S (2007). "Combined effects of fangchinoline from Stephania tetrandra Radix and formononetin and calycosin from Astragalus membranaceus Radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice". Biological & Pharmaceutical Bulletin 30 (11): 2079–83. doi:10.1248/bpb.30.2079. PMID 17978479. 

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