Stephen Oliver (scientist)

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For other people of the same name, see Stephen Oliver.
Stephen George Oliver
Born (1949-11-03) 3 November 1949 (age 64) [1]
Institutions UMIST
University of Cambridge
University of Kent[2]
University of Manchester[3]
University of California, Irvine[1][4]
National Institute for Medical Research[1]
Alma mater University of Bristol
Thesis The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae. (1975)
Doctoral students Kyangyu Yen[5][6]
Richard Harrison[7][8]
Chris Lockwood[9]
Walid Ahmed Mohamed Omara[10][11]
Known for Robot Scientist[12]
Systems Biology
Notable awards FMedSci (2002)
EMBO member (2004)
FAAAS (2008)

Stephen (Steve) George Oliver FMedSci FAAAS (born 3 November 1949) is a Professor in the Department of Biochemistry at the University of Cambridge,[13] director of the Cambridge Systems Biology Centre[14] and a Fellow of Wolfson College, Cambridge.[2]


Oliver was educated at the University of Bristol gaining a Bachelor of Science degree in Microbiology in 1971 followed by a PhD from the National Institute for Medical Research (NIMR) in 1974.[15]


Oliver's areas of research include functional genomics, systems biology[16][17][18][19][20][21] and drug discovery[22][23][24][25][26][27] using the model organism Saccharomyces cerevisiae[28] which he has worked on since the 1970s.[29] In 1992, whilst working at UMIST, Oliver led the team which provided first complete sequence analysis of an entire chromosome from any organism.[30] More recently he has also been involved in the creation of a Robot Scientist[12][31] and has been awarded research funding as principal investigator or co-investigator with a total value of over £26 million by the Biotechnology and Biological Sciences Research Council.[32]


  1. ^ a b c "‘OLIVER, Prof. Stephen George’, Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press, Dec 2012". (subscription required)
  2. ^ a b "Professor Steve Oliver | Wolfson College Cambridge". Archived from the original on 2013-01-04. 
  3. ^ Cornell, M.; Paton, N. W.; Oliver, S. G. (2004). "A critical and Integrated View of the Yeast Interactome". Comparative and Functional Genomics 5 (5): 382–402. doi:10.1002/cfg.412. PMC 2447467. PMID 18629175.  edit
  4. ^ Oliver, S. (1977). "On the mutability of the yeast mitochondrial genome". Journal of Theoretical Biology 67 (2): 195–201. doi:10.1016/0022-5193(77)90193-X. PMID 330960.  edit
  5. ^ Yen, Kuangyu (2007). Experimental and bioinformatic analyses of the functional equivalence between yeast and human genes in protein secretion (PhD thesis). University of Manchester. 
  6. ^ Yen, K.; Gitsham, P.; Wishart, J.; Oliver, S. G.; Zhang, N. (2003). "An improved tetO promoter replacement system for regulating the expression of yeast genes". Yeast 20 (15): 1255–1262. doi:10.1002/yea.1037. PMID 14618563.  edit
  7. ^ Harrison, Richard (2008). Exploring environmentally-dependent genetic variation in the yeast Saccharomyces cerevisiae (PhD thesis). University of Manchester. 
  8. ^ Harrison, R.; Papp, B.; Pal, C.; Oliver, S. G.; Delneri, D. (2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences 104 (7): 2307–2312. doi:10.1073/pnas.0607153104. PMC 1892960. PMID 17284612.  edit
  9. ^ Lockwood, Christopher Robert (2008). Can gains and losses of transcription factor binding sites be related to what occurs elsewhere in the regulatory region? (PhD thesis). University of Manchester. 
  10. ^ Omara, Walid Ahmed Mohamed (2009). Towards production and delivery of HPV16-L1 vaccine using genetically modified yeast (PhD thesis). University of Manchester. 
  11. ^ Omara, W. A. M.; Rash, B. M.; Hayes, A.; Wickham, M. S. J.; Oliver, S. G.; Stateva, L. I. (2010). "Conditional cell-wall mutants of Saccharomyces cerevisiae as delivery vehicles for therapeutic agents in vivo to the GI tract". Journal of Biotechnology 147 (2): 136–143. doi:10.1016/j.jbiotec.2010.03.010. PMID 20356564.  edit
  12. ^ a b King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature 427 (6971): 247–252. doi:10.1038/nature02236. PMID 14724639.  edit
  13. ^ Research in the Department of Biochemistry
  14. ^ "Steve Oliver — Cambridge Systems Biology Centre". Archived from the original on 2013-01-04. 
  15. ^ Oliver, Stephen (1975). The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae (PhD thesis). Council for National Academic Awards. 
  16. ^ List of publications from Microsoft Academic Search
  17. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970.  edit
  18. ^ Goffeau, A.; Barrell, B. G.; Bussey, H.; Davis, R. W.; Dujon, B.; Feldmann, H.; Galibert, F.; Hoheisel, J. D.; Jacq, C.; Johnston, M.; Louis, E. J.; Mewes, H. W.; Murakami, Y.; Philippsen, P.; Tettelin, H.; Oliver, S. G. (1996). "Life with 6000 Genes". Science 274 (5287): 546, 563–7. doi:10.1126/science.274.5287.546. PMID 8849441.  edit
  19. ^ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology 19 (1): 45–50. doi:10.1038/83496. PMID 11135551.  edit
  20. ^ Steve Oliver's publications in PubMed
  21. ^ Steve Oliver profile in BiomedExperts
  22. ^ Kell, D. B.; Dobson, P. D.; Bilsland, E.; Oliver, S. G. (2012). "The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so". Drug Discovery Today. doi:10.1016/j.drudis.2012.11.008. PMID 23207804.  edit
  23. ^ Lanthaler, K.; Bilsland, E.; Dobson, P. D.; Moss, H. J.; Pir, P. N.; Kell, D. B.; Oliver, S. G. (2011). "Genome-wide assessment of the carriers involved in the cellular uptake of drugs: A model system in yeast". BMC Biology 9: 70. doi:10.1186/1741-7007-9-70. PMC 3280192. PMID 22023736.  edit
  24. ^ Kell, D. B.; Dobson, P. D.; Oliver, S. G. (2011). "Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only". Drug Discovery Today 16 (15–16): 704–714. doi:10.1016/j.drudis.2011.05.010. PMID 21624498.  edit
  25. ^ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology 4: 145. doi:10.1186/1752-0509-4-145. PMC 2988745. PMID 21029416.  edit
  26. ^ Dobson, P. D.; Lanthaler, K.; Oliver, S. G.; Kell, D. B. (2009). "Implications of the dominant role of transporters in drug uptake by cells". Current topics in medicinal chemistry 9 (2): 163–181. PMID 19200003.  edit
  27. ^ Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E.; Smallbone, K.; Spasić, I.; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology 26 (10): 1155–1160. doi:10.1038/nbt1492. PMID 18846089.  edit
  28. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970.  edit
  29. ^ Oliver, S. G.; Williamson, D. H. (1976). "The molecular events involved in the induction of petite yeast mutants by fluorinated pyrimidines". MGG Molecular & General Genetics 146 (3): 253–259. doi:10.1007/BF00701248.  edit
  30. ^ Oliver, S. G.; Van Der Aart, Q. J. M.; Agostoni-Carbone, M. L.; Aigle, M.; Alberghina, L.; Alexandraki, D.; Antoine, G.; Anwar, R.; Ballesta, J. P. G.; Benit, P.; Berben, G.; Bergantino, E.; Biteau, N.; Bolle, P. A.; Bolotin-Fukuhara, M.; Brown, A.; Brown, A. J. P.; Buhler, J. M.; Carcano, C.; Carignani, G.; Cederberg, H.; Chanet, R.; Contreras, R.; Crouzet, M.; Daignan-Fornier, B.; Defoor, E.; Delgado, M.; Demolder, J.; Doira, C.; Dubois, E. (1992). "The complete DNA sequence of yeast chromosome III". Nature 357 (6373): 38–46. doi:10.1038/357038a0. PMID 1574125.  edit
  31. ^ King, P.; Rowland, J.; Aubrey, W.; Liakata, M.; Markham, M.; Soldatova, L. N.; Whelan, K. E.; Clare, A.; Young, M.; Sparkes, A.; Oliver, S. G.; Pir, P. (2009). "The Robot Scientist Adam". Computer 42 (7): 46 – 54. doi:10.1109/MC.2009.270.  edit
  32. ^ "BBSRC Grants awarded to Stephen Oliver". Retrieved 2011-07-04.