Upson was born in Waterbury, Connecticut, and graduated from Yale College in 1804. He then studied law at the Litchfield Law School. In 1807, Upson, moved to Hoover, Virginia, and later to Lexington, Georgia in order to study law under William H. Crawford. In 1812, Upson married Hannah Cummins. He represented Oglethorpe County, Georgia in the Georgia General Assembly beginning in 1820 and continued in that role until his death. Upson was also the head of the Georgia bar.
- Men of Mark in Georgia, A. B. Caldwell, 1912, pp.406-408
- GeorgiaInfo Upson County Courthouse History
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