Steroid-induced osteoporosis

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Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone (7.5 mg of prednisolone), especially when this is in excess of three months.[1][2] Alternate day use may not prevent this complication.[3] Osteoporosis may arise after taking steroids.

Mechanisms of SIOP include:[4]

  • Direct inhibition of osteoblast function
  • Direct enhancement of bone resorption
  • Inhibition of gastrointestinal calcium absorption
  • Increased urine calcium loss
  • Inhibition of sex steroids

References[edit]

  1. ^ Bone and Tooth Society of Great Britain, National Osteoporosis Society, Royal College of Physicians (2003). Glucocorticoid-induced Osteoporosis. London, UK: Royal College of Physicians of London. ISBN 1-86016-173-1. 
  2. ^ Cochrane Reviews. [url=http://summaries.cochrane.org/CD000952/calcium-and-vitamin-d-for-treating-osteoporosis-caused-by-the-use-of-steroids "Calcium and vitamin D for treating osteoporosis caused by the use of steroids"]
  3. ^ Gourlay M, Franceschini N, Sheyn Y (2007). "Prevention and treatment strategies for glucocorticoid-induced osteoporotic fractures". Clin Rheumatol 26 (2): 144–53. doi:10.1007/s10067-006-0315-1. PMID 16670825. 
  4. ^ Steroid-induced osteoporosis By Susan Ott, MD. Updated January 28, 2009. Retrieved on 26 March 2009