Steroid sulfatase

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Steroid sulfatase (microsomal), isozyme S
Protein STS PDB 1p49.png
PDB rendering based on 1p49.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STS ; ARSC; ARSC1; ASC; ES; SSDD; XLI
External IDs OMIM300747 HomoloGene47918 ChEMBL: 3559 GeneCards: STS Gene
EC number 3.1.6.2
RNA expression pattern
PBB GE STS 203767 s at tn.png
PBB GE STS 203768 s at tn.png
PBB GE STS 203769 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 412 n/a
Ensembl ENSG00000101846 n/a
UniProt P08842 n/a
RefSeq (mRNA) NM_000351 n/a
RefSeq (protein) NP_000342 n/a
Location (UCSC) Chr X:
7.14 – 7.27 Mb
n/a
PubMed search [1] n/a

Steroid sulfatase (or steryl-sulfatase), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.[1]

Function[edit]

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid. This includes sulfated androgens and sulfated estrogens. The encoded protein is found in the endoplasmic reticulum, where it is present as a homodimer.[1]

Clinical significance[edit]

A deficiency is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000-6,000 males.[2][3]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]