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Stiripentol structure.svg
Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status
  • AU: Unscheduled
Routes Oral
CAS number 49763-96-4 N
ATC code N03AX17
PubChem CID 5311454
ChemSpider 4470940 YesY
KEGG D05928 YesY
Chemical data
Formula C14H18O3 
 N (what is this?)  (verify)

Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is unrelated to other anticonvulsants and belongs to the group of aromatic allylic alcohols.

Mechanism of action[edit]

As with most anticonvulsants, the precise mechanism is unknown. It has been shown to have anticonvulsant effects on its own.

It increases GABA transmission. At clinically relevant concentrations, STP enhances central GABA transmission through a barbiturate-like effect, since it increases the duration of opening of GABA-A receptors channels in hippocampal slices.[1] It has also been shown that STP may increase the GABA levels in brain tissues and by interfering with its uptake and its metabolism.[2]

It also improves the effectiveness of many other anticonvulsants, possibly due to it inhibiting certain enzymes. This slows the drug's metabolism, increasing blood plasma levels.


In December 2001 the European Medicines Agency (EMA) granted stiripentol orphan drug status (designation number EU/3/01/071) for the treatment of severe myoclonic epilepsy in infancy (SMEI, also known as Dravet's syndrome). On 4 January 2007, the EMA granted the drug a marketing authorisation that is valid throughout the European Union.

Indications and usage[edit]

It is indicated as an adjunctive therapy with sodium valproate and clobazam for treating severe myoclonic epilepsy in infancy (SMEI)[3] whose seizures are not adequately controlled with clobazam and valproate. Children with SMEI develop often intractable seizures during their first year of life and [developmental delay] follows. Small-scale trials have shown remarkably high response rates, with a significant minority of those treated becoming seizure free.

In addition, it may be used to treat refractory childhood epilepsy in conjunction with carbamazepine. It appears to be less effective in adolescents and adults.


Stiripentol is available as a gelatine capsule (250 mg, 500 mg) and as a sachet of powder to make a drinkable suspension (250 mg, 500 mg).

Initial dose is 50 mg/kg per day. This may be increased up to 100 mg/kg per day, with a maximum of 4g. The dose to be divided into two or three with meals. The dose of other anticonvulsants may have to be reduced (possibly up to 50%).

Side effects[edit]

Side effects are largely due to the increase in plasma concentrations of other anticonvulsants and can be reduced by lowering the dose of those drugs. Nausea and vomiting are particularly noted when used in combination with sodium valproate.

Drug interactions[edit]

Stiripentol inhibits several cytochrome P450 isoenzymes and so interacts with many anticonvulsants and other medicines. This is both a strength and weakness. It appears to increase the potency of phenobarbital, primidone, phenytoin, carbamazepine, clobazam and diazepam. For example, blood levels of carbamazepine can be maintained while reducing the dose by 50%.


  1. ^ Quilichini PP, Chiron C, Ben-Ari Y, Gozlan H (2006). "Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels". Epilepsia : PR 47 (4): 704–16. doi:10.1111/j.1528-1167.2006.00497.x. PMID 16650136. 
  2. ^ Trojnar MK, Wojtal K, Trojnar MP, Czuczwar SJ (2005). "Stiripentol. A novel antiepileptic drug". Pharmacological reports : PR 57 (2): 154–60. PMID 15886413. 
  3. ^ Thanh TN, Chiron C, Dellatolas G, et al. (November 2002). "[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)]". Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie (in French) 9 (11): 1120–7. PMID 12503502. 

Further reading[edit]

  • Tran A, Vauzelle-Kervroedan F, Rey E, et al. (1996). "Effect of stiripentol on carbamazepine plasma concentration and metabolism in epileptic children". European journal of clinical pharmacology 50 (6): 497–500. doi:10.1007/s002280050147. PMID 8858278. 

External links[edit]