The district was governed by the Strand District Board of Works, which consisted of forty-nine elected vestrymen: eighteen elected for the parish of St Anne Soho; fifteen for St Clement Danes; nine for St Paul Covent Garden; three each for St Mary le Strand and the Liberty of the Rolls and one for the Precinct of the Savoy. The first elections were held in November 1855, when the entire membership of the board was elected. Thereafter elections for one third of the seats were held in May, beginning in the year 1857.
In 1899, the London Government Bill was introduced to parliament. The Bill sought to abolish the vestries and district boards in London and replace them with twenty-eight metropolitan boroughs. One of the boroughs included in the schedule to the Bill grouped together Strand District with the areas of three other boards and vestries in the Westminster area as a new borough. This was vigorously resisted by the Strand District Board of Works along with the vestries of St Martin in the Fields and St James Westminster. Instead of what they dubbed "Greater Westminster", the three authorities instead proposed a Metropolitan Borough of The Strand, separate from Westminster, and with the same boundaries as the parliamentary borough of that name. The campaign met with no success, and on November 1, 1900, the Strand District became part of the Metropolitan Borough of Westminster.