The group went outside its past self-production and got help from future star producers Buckwild and Rockwilder. The album features O.C. and A Tribe Called Quest's Q-Tip. The album's tone is generally darker than that of its predecessor, with subject matter falling under the album's title.
The cover was painted by the late Matt Reid AKA Matt Doo of Dooable Arts, who later committed suicide. Prince Po later would later write "Be Easy", a song dedicated to him from his album The Slickness. He also designed the cover for Company Flow's seminal Funcrusher Plus.
Stress: The Extinction Agenda was well received and is considered to be an underground hip hop classic. Spin magazine included it on Spin's list of the "10 Best Albums You Didn't Hear In '95".
The Source gave it 4 stars out of 5 and said that, "The essence of Organized Konfusion is pure lyricism. More so than any other artists out now, Monch and Prince are masters of words and phrases... they become verbal contortionists, creating moving molecules of syllables and sounds." In 1998, the album was included as one of The Source's 100 Best Rap Albums.
Rap Pages said, "This is a must-have LP for any aspiring lyricist, as well as for avid fans who are tired of the saturated, unexceptional, untalented, crime-related, or sexual, close-minded MCs."Urban Latino said, "[Organized Konfusion] create a sophisticated hip-hop style that is often as innovative as it is infectious... there's enough head-bobbing and bounce-type material here to keep the attention of even the most jaded listener."