Structural Genomics Consortium
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The Structural Genomics Consortium (SGC) is a not-for-profit organization formed in 2004 to determine the three-dimensional structures of proteins of medical relevance, and place them in the Protein Data Bank without restriction on use. The SGC operates out of the Universities of Oxford and Toronto. Over the past five years, the SGC has accounted for ~25% of the global output of novel human protein structures each year, and ~40% of the annual global output of structures of proteins from human parasites. The SGC target proteins have relevance to human health and disease, such as diabetes, cancer and infectious diseases such as malaria. The SGC is supported by funding from the Wellcome Trust, GSK, Novartis, Eli Lilly, Pfizer, Takeda, Abbott, Life Technologies, the Canadian Institutes for Health Research (CIHR), Canadian Foundation for Innovation (CFI), Genome Canada, the Ontario's Ministry of Economic Development and Innovation (MEDI). Recently, these organizations together have committed more than US$65 million to the consortium to sustain operation from 2011 to 2015.
The SGC is also spearheading an "open access" chemistry partnership – a new model for pre-competitive drug discovery in which the public and private sectors collaborate to generate potent and selective pharmacological inhibitors of human proteins that regulate epigenetic signalling, and commit to make these reagents available without restriction on use.
In 2011, the SGC launched a project to create high-quality recombinant antibodies to proteins implicated in epigenetic events in an effort to stimulate research on these proteins. The project is carried out in partnership with leading academic research groups in the field (Tony Kossiakoff and Shohei Koide at University of Chicago, Sachdev Sidhu at the University of Toronto) and the laboratory of Jack Greenblatt at the University of Toronto. These reagents will be made available without restriction on use.
Highlight publications (2008–2012)
- Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Liu, Feng; Rival-Gervier, Sylvie; Allali-Hassani, Abdellah; Labrie, Viviane; Wigle, Tim J; Dimaggio, Peter A et al. (2011). "A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells". Nature Chemical Biology 7 (8): 566–74. doi:10.1038/nchembio.599. PMC 3184254. PMID 21743462.
- Colwill, Karen; Persson, Helena; Jarvik, Nicholas E; Wyrzucki, Arkadiusz; Wojcik, John; Koide, Akiko; Kossiakoff, Anthony A; Koide, Shohei et al. (2011). "A roadmap to generate renewable protein binders to the human proteome". Nature Methods 8 (7): 551–8. doi:10.1038/nmeth.1607. PMID 21572409.
- Filippakopoulos, Panagis; Qi, Jun; Picaud, Sarah; Shen, Yao; Smith, William B.; Fedorov, Oleg; Morse, Elizabeth M.; Keates, Tracey et al. (2010). "Selective inhibition of BET bromodomains". Nature 468 (7327): 1067–73. doi:10.1038/nature09504. PMC 3010259. PMID 20871596.
- Ceccarelli, Derek F.; Tang, Xiaojing; Pelletier, Benoit; Orlicky, Stephen; Xie, Weilin; Plantevin, Veronique; Neculai, Dante; Chou, Yang-Chieh et al. (2011). "An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme". Cell 145 (7): 1075–87. doi:10.1016/j.cell.2011.05.039. PMID 21683433.
- Barr, Alastair J.; Ugochukwu, Emilie; Lee, Wen Hwa; King, Oliver N.F.; Filippakopoulos, Panagis; Alfano, Ivan; Savitsky, Pavel; Burgess-Brown, Nicola A. et al. (2009). "Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome". Cell 136 (2): 352–63. doi:10.1016/j.cell.2008.11.038. PMC 2638020. PMID 19167335.
- Avvakumov, George V.; Walker, John R.; Xue, Sheng; Li, Yanjun; Duan, Shili; Bronner, Christian; Arrowsmith, Cheryl H.; Dhe-Paganon, Sirano (2008). "Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1". Nature 455 (7214): 822–5. doi:10.1038/nature07273. PMID 18772889.
- Filippakopoulos, Panagis; Kofler, Michael; Hantschel, Oliver; Gish, Gerald D.; Grebien, Florian; Salah, Eidarus; Neudecker, Philipp; Kay, Lewis E. et al. (2008). "Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation". Cell 134 (5): 793–803. doi:10.1016/j.cell.2008.07.047. PMC 2572732. PMID 18775312.
- Gräslund, Susanne; Nordlund, Pär; Weigelt, Johan; Bray, James; Gileadi, Opher; Knapp, Stefan; Oppermann, Udo; Arrowsmith, Cheryl et al. (2008). "Protein production and purification". Nature Methods 5 (2): 135–46. doi:10.1038/nmeth.f.202. PMC 3178102. PMID 18235434.
For a complete listing click here.
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