- For other uses of analog, see Analog (disambiguation).
In chemistry, a structural analog (structural analogue), also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component.
It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound.
In drug development either a large series of structural analogs of an initial lead compound are created and tested as part of a structure-activity relationship study or a database is screened for structural analogs of a lead compound.
- Derivative (chemistry)
- Homolog, a compound of a series differing only by repeated units
- Functional analog, compounds with similar physical, chemical, biochemical, or pharmacological properties
- Transition state analog
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