Subcapsular sinus

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Lymph: Subcapsular sinus
Section of small lymph node of rabbit. X 100. (Subcapsular lymph path labeled at center left.)
Schematic of lymph node showing lymph sinuses.png
Schematic diagram of lymph node showing the flow of lymph through the lymph sinuses
Gray's p.689

The subcapsular sinus (lymph path, lymph sinus, marginal sinus) is a region within the lymph node immediately deep to the capsule that contains relatively sparse lymphocytes. It thus allows lymph to flow freely through it.[1]

The lymph node contains lymphoid tissue, i.e., a meshwork or fibers called reticulum with white blood cells enmeshed in it. The regions where there are few cells within the meshwork are known as lymph sinus. It is lined by reticular cells, fibroblasts and fixed macrophages.[1]

Thus, subcapsular (sub=below) sinus lies immediately deep to the capsule of the lymph node and immediately above the cortex. It is continuous with the similar lymph sinuses that flank the trabeculae (the extensions of the capsule within the substance of the lymph node).[1]

The subcapsular sinus has clinical importance as it is the most likely location where the earliest manifestations of a metastatic carcinoma in a lymph node would be found.


  1. ^ a b c Warwick, Roger; Peter L. Williams (1973) [1858]. "Angiology (Chapter 6)". Gray's anatomy. illustrated by Richard E. M. Moore (Thirty-fifth Edition ed.). London: Longman. pp. 588–785. 

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