Substantia gelatinosa of Rolando
|Substantia gelatinosa of Rolando (SGR)|
|Substantia gelatinosa of Rolando is Rexed lamina II, labeled at upper left.|
|Latin||substantia gelatinosa cornu posterioris medullae spinalis|
|Gray's||subject #185 753|
The apex of the posterior horn of the gray matter of the spinal cord is capped by a V-shaped or crescentic mass of translucent, gelatinous neuroglia, termed the substantia gelatinosa of Rolando (or SGR) (or gelatinous substance of posterior horn of spinal cord), which contains both neuroglia cells, and small nerve cells. The gelatinous appearance is due to a very low concentration of myelinated fibers.
It is named after Luigi Rolando.
C fibers terminate at this layer. Thus the cell bodies located here are part of the neural pathway conveying slowly conducting, poorly localized pain sensation. However, some A delta fibers (carrying fast, localized pain sensation) also terminate in the substantia gelatinosa, mostly via axons passing through the area of the nucleus proprius. Thus, there is cross talk between the two pain pathways.
- Baba H, Shimoji K, Yoshimura M (February 2000). "Norepinephrine facilitates inhibitory transmission in substantia gelatinosa of adult rat spinal cord (part 1): effects on axon terminals of GABAergic and glycinergic neurons". Anesthesiology 92 (2): 473–84. PMID 10691235.
- "SpringerLink - Journal Article".
It is not known, however, if cocaine acts on this pathway.
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