Sud-Comoé is one of the 19 regions of Côte d'Ivoire. The region's capital is Aboisso. Covering 6,250 km², its population (2002 est.) is 536,500.
The region is divided into four departments: Aboisso, Adiaké, Grand-Bassam and Tiapoum.
The region is virtually the same as the territory of the pre-colonial kingdom of Sanwi which as late as 1969 attempted to break away from Côte d'Ivoire and form an independent state. The current King of Sanwi is Nana Amon Ndoufou V (since 2002).
Coordinates: 5°30′N 3°15′W / 5.500°N 3.250°W / 5.500; -3.250