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Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status
CAS number 2447-57-6 YesY
ATCvet code QJ01EQ13
PubChem CID 17134
DrugBank DB01299
ChemSpider 16218 N
UNII 88463U4SM5 N
KEGG D00580 YesY
NIAID ChemDB 007816
Chemical data
Formula C12H14N4O4S 
Mol. mass 310.33 g/mol
 N (what is this?)  (verify)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria.[1] Due to high levels of resistance, its use is no longer recommended routinely.[2] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[3]

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]

Mechanism of action[edit]

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.

See also[edit]


  1. ^ Medical Treatment - Sulphadoxine and Pyrimethamine.
  2. ^ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania.". Malar J 13: 152. doi:10.1186/1475-2875-13-152. PMID 24751352. 
  3. ^
  4. ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.