Sulfanegen

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Sulfanegen
Sulfanegen.svg
Names
IUPAC name
2,5-Dihydroxy-1,4-dithiane-2,5-dicarboxylic acid
Identifiers
80003-64-1
ChemSpider 29395474
Jmol-3D images Image
PubChem 24830990
Properties
C6H8O6S2
Molar mass 240.25 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Sulfanegen is an experimental antidote for cyanide poisoning.[1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective.[2] Instead, prodrugs such as sulfanegen are being evaluated to compensate for the short half-life.[3]

Sulfanegen has been shown to be effective in animal studies.[4] It is being studied as the sodium salt, sulfanegen sodium, and the triethanolamine salt, sulfanegen TEA.[5][3]

One advantage sulfanegen may have over existing treatments for cyanide poisoning is that it might be administered by intramuscular injection rather than by intravenous infusion.[6]

References[edit]

  1. ^ "Researchers discover fast-acting cyanide antidote". phys.org. Dec 27, 2007. 
  2. ^ Nagahara, N; Li, Q; Sawada, N (2003). "Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?". Current drug targets. Immune, endocrine and metabolic disorders 3 (3): 198–204. doi:10.2174/1568008033340162. PMID 12871026. 
  3. ^ a b Brenner, M; Kim, JG; Lee, J; Mahon, SB; Lemor, D; Ahdout, R; Boss, GR; Blackledge, W; Jann, L; Nagasawa, HT; Patterson, SE (2010). "Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity". Toxicology and applied pharmacology 248 (3): 269–76. doi:10.1016/j.taap.2010.08.002. PMC 3382974. PMID 20705081. 
  4. ^ Chan, A; Crankshaw, DL; Monteil, A; Patterson, SE; Nagasawa, HT; Briggs, JE; Kozocas, JA; Mahon, SB; Brenner, M; Pilz, RB; Bigby, TD; Boss, GR (2011). "The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning". Clinical toxicology (Philadelphia, Pa.) 49 (5): 366–73. doi:10.3109/15563650.2011.584879. PMID 21740135. 
  5. ^ Belani, KG; Singh, H; Beebe, DS; George, P; Patterson, SE; Nagasawa, HT; Vince, R (2012). "Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium". Anesthesia and analgesia 114 (5): 956–61. doi:10.1213/ANE.0b013e31824c4eb5. PMC 3334426. PMID 22392971. 
  6. ^ "New Antidote for Cyanide Found". Yahoo News. February 1, 2013.