Sunepitron

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Sunepitron
Sunepitron.png
Systematic (IUPAC) name
1-{[2-(pyrimidin-2-yl)octahydro-2H-pyrido[1,2-a]pyrazin-7-yl]methyl}pyrrolidine-2,5-dione
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 148408-65-5
ATC code None
PubChem CID 9799246
ChemSpider 7975011
UNII 2GT50C8U60 YesY
KEGG D02569
ChEMBL CHEMBL380369
Chemical data
Formula C17H23N5O2 
Molecular mass 329.40 g/mol

Sunepitron (CP-93,393) is a combined 5-HT1A receptor agonist and α2-adrenergic receptor antagonist.[1][2] It was previously under development by Pfizer for the treatment of depression and anxiety.[3] It made it to phase III clinical trials before being discontinued.[2][3]

Synthesis[edit]

Sunepitron can be synthesized from a pyridine dicarboxylic acid:[4]

Sunepitron synth.png

See also[edit]

References[edit]

  1. ^ Goodnick PJ (July 1999). "Psychopharmacology of depression in the next millennium". CNS Spectrums 4 (7): 21–35. PMID 18438295. 
  2. ^ a b Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4. 
  3. ^ a b Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0. 
  4. ^ G.N. Bright, K.A. Desai, U.S. Patent 5,122,525 (1992)