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A superfamily refers to different concepts in different scientific fields:
- Superfamily (molecular biology), a large group of related proteins or other molecules
- SUPERFAMILY, a database of annotation for all proteins
- Superfamily, in zoology, a level of biological classification; redirects to Taxonomic rank
- Superfamily in comparative linguistics, another term for "macrofamily"
- Font superfamily, a large typographic family containing fonts from several classifications
- Superfamily (band), a Norwegian pop band
- The collective group of super beings from Krypton, and certain others, from DC Comics, often referred to as the "Super Family" as allies of Superman
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